Best 16 Penne Casserole Recipes

CHICKEN PENNE CASSEROLE

Steps:

• Preheat oven to 350°. Cook pasta according to package directions. Meanwhile, in a large saucepan, heat oil over medium heat. Add chicken, onion, peppers and seasonings; saute until chicken is no longer pink. Add garlic; cook 1 minute longer., In a blender, pulse tomatoes and tomato paste, covered, until blended. Add to chicken mixture. Stir in broth; bring to a boil over medium-high heat. Reduce heat; cover and simmer until slightly thickened, 10-15 minutes. , Drain pasta; toss with chicken mixture. Spoon half of the mixture into a greased 2-qt. baking dish. Sprinkle with half of the cheeses. Repeat layers. , Cover and bake 30 minutes. Uncover; bake until heated through, 15-20 minutes longer.

PORTOBELLO PENNE PASTA CASSEROLE

Steps:

• Preheat oven to 350 degrees F (175 degrees C). Lightly grease a 9x13 inch baking dish.
• Bring a large pot of lightly salted water to a boil. Place pasta in the pot, cook for 8 to 10 minutes, until al dente, and drain.
• Heat the oil in a saucepan over medium heat. Stir in the mushrooms, cook 1 minute, and set aside. Melt margarine in the saucepan. Mix in flour, garlic, and basil. Gradually mix in milk until thickened. Stir in 1 cup cheese until melted. Remove saucepan from heat, and mix in cooked pasta, mushrooms, spinach, and soy sauce. Transfer to the prepared baking dish, and top with remaining cheese.
• Bake 20 minutes in the preheated oven, until bubbly and lightly brown.

PESTO CHICKEN PENNE CASSEROLE

Steps:

• Preheat an oven to 350 degrees F (175 degrees C). Grease a 9x13-inch baking dish. Combine the bread crumbs, Parmesan cheese, and olive oil in a small bowl until evenly moistened; set aside.
• Fill a large pot with lightly salted water and bring to a rolling boil over high heat. Once the water is boiling, stir in the penne, and return to a boil. Cook the pasta uncovered, stirring occasionally, until the pasta has cooked through, but is still firm to the bite, about 11 minutes. Drain well in a colander set in the sink.
• Meanwhile, combine the chicken in a bowl with the Italian cheese blend, spinach, tomatoes, alfredo sauce, pesto sauce, and milk. Stir in the pasta once done, and scoop into the prepared baking dish. Top with the bread crumb mixture.
• Bake in the preheated oven until bubbly and golden brown on top, 40 to 45 minutes.

CHEESY HAM-PENNE CASSEROLE

Steps:

• Set oven to 350 degrees F.
• Grease a 13 x 9-inch baking dish.
• Place the cooked penne and the ham into a large bowl; set aside.
• In a medium saucepan melt butter over medium heat.
• Add in mustard powder, black pepper, seasoned salt and cayenne pepper and onion, stir and cook for about 4 minutes.
• Add in garlic; cook stirring for 2 minutes.
• Add in flour and mix continously for 2 minutes.
• Slowly add in the cream and 1/3 cup Parmesan cheese; cook stirring over medium-low heat until bubbly.
• Reduce heat to low and stir in the cheddar cheese until completely melted.
• Pour the sauce over the cooked pasta and ham; toss until well combined.
• Transfer to a greased baking dish.
• Sprinkle the top with about 1/3 cup or more Parmesan cheese.
• Cover and bake in a 350 degree F oven for about 45 minutes or until hot and bubbly.

PENNE AND SMOKED SAUSAGE CASSEROLE

Steps:

• Cook pasta according to package directions. Meanwhile, in a large skillet, brown sausage over medium heat for 5 minutes; drain. In a large bowl, combine milk and soup. Stir in 1/2 cup onions, 1/2 cup mozzarella cheese, 1/2 cup cheddar cheese and sausage. Drain pasta; stir into sausage mixture., Transfer to a greased 3-qt. baking dish. Cover and bake at 375° until bubbly, 25-30 minutes. Sprinkle with remaining onions and cheeses. Bake, uncovered, until cheese is melted, 3-5 minutes longer.

BAKED PENNE BOLOGNESE CASSEROLE

Steps:

• PREHEAT oven to 350°F.
• COMBINE beef, onion and garlic in large saucepan; cook over medium-high heat, stirring occasionally, for 5 to 6 minutes or until beef is no longer pink. Drain. Stir in tomato paste, water, milk, wine, bouillon and Italian herb seasoning; cook, stirring occasionally, for 10 to 15 minutes or until flavors are blended.
• LAYER ingredients as follows in 13 x 9-inch baking dish: half of pasta, half of sauce and half of cheese. Repeat layers; cover.
• BAKE for 20 to 25 minutes or until heated through.

PENNE AND MEATBALL CASSEROLE

Steps:

• Preheat the oven to 350 degrees F (175 degrees C). Coat a baking sheet and a 1-quart baking dish with cooking spray.
• Bring a large pot of lightly salted water to a boil. Add penne and cook, stirring occasionally, until tender yet firm to the bite, about 11 minutes.
• Meanwhile, combine bread crumbs, 2 tablespoons Parmesan cheese, egg substitute, Italian seasoning, onion powder, salt, and garlic powder in a bowl. Crumble turkey on top and mix well. Shape mixture into 1/2-inch balls and place on the prepared baking sheet.
• Bake in the preheated oven until no longer pink in the centers, 9 to 11 minutes. Drain off excess grease.
• Drain penne. Combine baked meatballs with spaghetti sauce in a bowl. Spoon 1/2 the mixture into the prepared baking dish. Top with 1/2 of the cooked penne, cottage cheese, and mozzarella cheese, plus 1 tablespoon Parmesan cheese. Repeat layers. Cover with a glass lid or aluminum foil.
• Bake in the preheated oven until cheese is melted, 20 to 25 minutes.

CRAB 'N' PENNE CASSEROLE

Steps:

• Preheat oven to 325°. Cook pasta according to package directions. , Meanwhile, in a large bowl, combine Alfredo sauce, crab, yellow squash, zucchini, parsley and pepper flakes. Drain pasta; add to sauce mixture and toss to coat. Transfer to a greased 13x9-in. baking dish. Sprinkle with cheese. , Cover and bake 35 minutes or until heated through. Toss bread crumbs and butter; sprinkle over casserole. Bake, uncovered, 5-6 minutes longer or until browned.

CHICKEN PENNE CASSEROLE

Steps:

• Cook pasta according to package directions.
• Saute the chicken, onion, peppers, garlic and seasonings in oil until chicken is no longer pink.
• Combine tomatoes and tomato paste.
• Add to chicken mixture.
• Stir in broth and bring to a boil.
• Reduce heat, cover and simmer for 10-15 minutes or until slightly thickened.
• Drain pasta and toss with chicken mixture.
• Spoon half of the chicken mixture into a greased baking dish.
• Sprinkle with half of the mozzarella and Romano cheeses.
• Repeat layers.
• Cover and bake at 350 for 30 minutes.
• Uncover and bake 15-20 minutes longer or until heated through.

CHICKEN PENNE PASTA CASSEROLE

Steps:

• 1. Take a large pot and fill over halfway with water and add salt to cook your penne in. Let it start heating up while you prep all the other ingredients.
• 2. Preheat the oven to 350. Take a large casserole dish and coat it with olive oil and or pam inside. Make sure there are no places that are not oiled and set aside.
• 3. Take the 2 large chicken breasts and cube them into bite size pieces and add to a bowl once done. Wash your hands thoroughly after cutting the chicken up. Using a different cutting board dice up your red onion.
• 4. Take your can of black olives and drain well. Cut them into halves and put them into a separate small bowl for later usage.
• 5. Using a wok or a large sautee pan add the olive oil to the pan and allow to heat up. Once ready add the chicken breasts, onions, minced garlic, herbs and seasonings. Stir this mixture till the chicken is fully cooked.
• 6. Once the chicken is fully cooked add the jar of tomato sauce, the undrained diced tomatoes and bring this mixture up to a light boil. Drop it down to a slow simmer till the pasta is done.
• 7. While the sauce is simmering add your penne to the boiling and salted water. Cook following the directions on the package.
• 8. Once the pasta is cooked drain it very well. Cut the heat off on the sauce and add the pasta to the pan then add the black olives. Stir very well making sure everything is coated and mixed together nicely.
• 9. Slowly add this mixture to your casserole dish making sure to get everything out of your pan. Top with the sliced fresh mozzarella cheese and place into the oven.
• 10. Bake till the cheese is melted and a nice golden brown approximately about 30 minutes, but check it after about 20 mins. Once cheese is melted and golden brown remove from the oven. Hope you all enjoy this dish as much as we did.

CHICKEN AND PENNE CASSEROLE

Steps:

• Set oven to 375 degrees F.
• Butter a 13 x 9-inch baking dish.
• Heat oil in a skillet.
• Season the chicken with salt and pepper, then brown on both sides about 5 minutes per side; transfer to a plate.
• Add in onion, garlic, oregano, basil and crushed red pepper flakes; saute about 5 minutes.
• Add in the crushed tomatoes, stewed tomatoes with juice, wine, sugar and bay leaf; cook for about 35-40 minutes, season with salt and pepper.
• Line the bottom of the dish with cooked penne pasta, sprinkle the top with about 1/3 cup grated Parmesan cheese.
• Arrange the browned chicken pieces on top of the cooked pasta.
• Remove bay leaf and spoon the sauce over the chicken covering chicken and pasta completely.
• Mix the mozzarella cheese with 1/3 cup Parmesan cheese, then sprinkle over the top of the sauce.
• Bake for about 20 minutes, or until the chicken is cooked and the sauce is bubbly.
• Delicious.

GREEK STYLE PENNE CASSEROLE

Steps:

• Cut chicken breasts into small cubes; saute until just cooked through.
• Sprinkle seasonings over top, stir to distribute evenly and add canned tomatoes and sauce.
• Stir to deglaze and bring sauce to simmer while cooking pasta.
• Bring large pot of water to boil; stir in penne and cook until al dente, approximately 9-10 minutes.
• Drain thoroughly.
• Stir egg and 1/2 of feta cheese together; add to pasta.
• Layer pasta in casserole dish or 8 x 12 inch baking pan sprayed with cooking oil spray.
• Pour sauce over top (sauce will be thin and will settle throughout pasta).
• Sprinkle with remaining cheese.
• Bake in preheated 350 degree oven for 20-25 minutes or until heated through and lightly browned on top.

ELLEN'S BAKED PENNE PASTA CASSEROLE

Steps:

• 1. In a large pot, cook penne pasta according to package directions; drain and set aside.
• 2. In a large saucepan, melt butter and cook onion and garlic for about 3 minutes or until tender. Add the spaghetti sauce, basil, oregano, and half the mozzarella cheese. Stir to blend and allow mozzarella to melt.
• 3. Add the pasta to the sauce mixture and combine thoroughly. Pour into a greased 7x9x2" Pyrex baking dish. Top with the remaining mozzarella and all of the hot pepper jack cheese.
• 4. Cover dish and bake in a preheated 375-degree oven for 20 minutes. Uncover and bake an additional 5 minutes or until bubbly. Top with Parmesan cheese and serve hot.

OVEN PENNE RIGATE CASSEROLE

Steps:

• Preheat oven to 350°F Prepare penne as package requires, drain. In large bowl, combine cooked pasta, vegan sausage, sauce, and 1 cup of cheese. Pour all ingredients into a greased 2-1/2 quart shallow baking dish and cover. Bake 30 minutes or until it is bubbling. Uncover, top with remaining cheese and bake for another 8 minutes. Dig in & don't forget to refrigerate any left overs!

PORTOBELLO PENNE PASTA CASSEROLE

Steps:

• Preheat oven to 350 degrees F (175 degrees C). Lightly grease a 9x13 inch baking dish.

COPIA'S PENNE PASTA AND CHEESE CASSEROLE

Steps:

• Preheat an oven to 350 degrees F (175 degrees C).
• Fill a large pot with lightly salted water and bring to a rolling boil over high heat. Once the water is boiling, stir in the penne, and return to a boil. Cook the pasta uncovered, stirring occasionally, until the pasta has cooked through, but is still firm to the bite, about 11 minutes. Drain well in a colander set in the sink.
• Place the bacon in a large, deep skillet, and cook over medium-high heat, turning occasionally, until evenly browned, about 10 minutes. Drain the bacon slices on a paper towel-lined plate, and reserve the remaining bacon drippings in a small bowl. Crumble the bacon into a bowl, then mix in the panko bread crumbs, butter, and chopped parsley. Set aside.
• Heat the olive oil in a skillet over medium heat. Stir in the garlic and shallots; cook and stir until the shallots have softened and turned translucent, about 5 minutes. Stir in the bacon drippings and flour. Cook and stir for 1 minute, then whisk in the heavy cream and thyme. Continue to cook and stir until reduced by 1/3. Add Monterey Jack cheese and Cheddar cheese, stirring until cheeses have melted. Season with salt and pepper. Stir in the penne pasta. Transfer the pasta mixture to a 9x13-inch baking dish. Sprinkle with the bread crumb mixture.
• Bake in the preheated oven until bread crumbs have browned and the sauce is bubbly, about 25 minutes.